All times are Cairo time (GMT+2)
First leg
Sunday 29 October
15:00 Mamelodi Sundowns (South Africa) vs. Ahly (Egypt)
15:00 Wydad Casablanca (Morocco) vs. Esperance (Tunisia)
Second leg
Wednesday 1 November
18:00 Esperance (Tunisia) vs. Wydad Casablanca (Morocco)
20:00 Ahly (Egypt) vs. Mamelodi Sundowns (South Africa)
