The Barcelona forward suffered a Grade 2 Medial Collateral Ligament strain in the eighth minute of their opening Group C game against South Africa on Monday.
Oshoala received treatment and returned to the field of play until she was substituted in the 82nd minute by Francesca Ordega.
The Nigerian Football Federation confirmed on their official Twitter account that Oshoala was out of the tournament, though Super Falcons head coach Randy Waldrum declined to comment on her absence as the nine-time record African champions prepare to take on Botswana in their second tie at the tournament tomorrow.
The American tactician, however, revealed that, “We are definitely going to make some changes from our first game. The atmosphere in camp is good and we have regrouped. We want to win our next game.”
Nigeria currently sit third in Group C behind table leaders Botswana and second-placed South Africa who both won their opening games.